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Abstract
Overuse, misuse, and underuse of antibiotic and other drug molecules is a big problem. Self-medication always a keen interest in human beings. This lead to the development of complicated multidrug-resistant bacteria. Normal antibiotics having less efficacy against them. Natural plant products used for therapeutic purposes from ancient times. It has been observed that conjugation of these antibiotics with certain plant products increases the efficacy of the drug against the pathogen. Black pepper is a well-known spice used in Indian cuisine and has antimicrobial properties. In presented work, we have used Piper nigrum along with standard antibiotics available in the market to check the efficacy of the combination against E.coli, Bacillus subtilis and S. aureus.