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Abstract
The biological function of the body is controlled by circadian rhythm which is composed by Suprachiasmatic nucleus (SCN) where brain circulates the information to different cells/tissue of the body that make easier for living being to adjust in environment at any time. Hypertension is one of the most common diseasesfor high rate of morbidity all over the world.The change in blood pressure (BP) and heart rate (HR) is due to 24-hrs circadian rhythm. Chronotherapy plays a vital role in the management of hypertension where patients have to take medication once a day i.e. either in morning or in bedtime. The change in pharmacokinetic and pharmacodynamic of drug had observed due to different time of administration. Administration of antihypertension drugs such as valsartan given during nighttime decreases both diurnal as well as nocturnal BP and reduces excretion of albumin from urine.Various chronopharmaceutical approaches develop to achieve chronotherapy such as pulsatile system, floating system.