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Abstract
Imidazole, a five membered heterocyclic compound, with two nitrogen atoms at positions 1 and 3 respectively exhibits a wide range of pharmacological action such asanti-fungal, anti-bacterial, anti-tubercular, anti-viral, anti-inflammatory, analgesic, anti-depressant, anti-cancer, carbonic anhydrase inhibitor, anti-ulcer, anthelmintic, anti-amoebic, anti-hypertensive, anti-epileptic, anti-psychotic and anti-emetic.A number of drugs having imidazole nucleus are available in the market for clinical use.Some of these marketed drugs are ketoconazole, omeprazole, mebendazole, acyclovir, secnidazolepimozide, and ondansetron.Various derivatives of imidazole nucleus have been synthesized and screened for their pharmacological activities.There are a number of well-established protocols for the synthesis of this heterocyclic ring. This paper summarizes some of the approaches of synthesis of imidazole derivatives having different pharmacological activities.